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MooTools (50,894) is a collection of JavaScript utilities designed for the intermediate to advanced JavaScript developer. It allows you to write powerful and flexible code with its elegant, well documented, and coherent APIs.
Dojo (349,433) is a JavaScript toolkit that saves you time and scales with your development process. It provides everything you need to build a Web app: language utilities, UI components, and more, all in one place, designed to work together perfectly.
Prototype (363,128) takes the complexity out of client-side web programming. Built to solve real-world problems, it adds useful extensions to the browser scripting environment and provides elegant APIs around the clumsy interfaces of Ajax and the Document Object Model.
YUI is a free, open-source JavaScript and CSS library for building richly interactive web applications.